Prussian blue

Consult latest REMM online version for current details.

http://www.remm.nlm.gov/int_contamination.htm#blockingagents

Administered for Isotopes:
-- FDA-approved for Rx of known or suspected internal contamination with radioactive Cs and/or radioactive or non-radioactive thallium
--FDA-approved for ages > 2 years old only

Route of Administration
--PO
--Capsules may be opened and contents mixed with food

Dosage
Adults, children >12 years
--1-3 g (2-6 capsules; 0.5 g insoluble Prussian blue per cap) TID; up to 10-12 g/day
--3 g (6 capsules; 0.5 g insoluble Prussian blue per cap) TID (see: FDA Package Insert )
Children 2 - 12 years
--1 g (2 capsules; 0.5 g insoluble Prussian blue per cap) TID
Children <2 years
--Prussian blue is not FDA-approved for use (IND or EUA may be required)

Duration of treatment
--Minimum 30 day course per FDA
--Obtain bioassay and whole body counting to assess treatment of efficacy
--Duration of therapy depends on total body burden and response to treatment

Mechanism of action
-- Ion exchange; inhibits enterohepatic recirculation in GI tract