Ca-DTPA, Zn-DTPA

Consult latest REMM online version for current details:

http://www.remm.nlm.gov/int_contamination.htm#blockingagents

Administered for Isotopes
-- FDA-approved for intravenous Rx of known or suspected internal contamination with Am, Cm, and Pu only
-- FDA-approved for nebulized inhalation in adults only, and if the only route of contamination is through inhalation

Route of Administration
--IV (give once daily as a bolus or as a single infusion, i.e., do not fractionate the dose)
--Nebulized inhalation (for use in adults only)

Dosage
IV administration
--Adults: 1 g in 5 cc 5% dextrose in water (D5W) or 0.9% sodium chloride (normal saline, NS) slow IV push over 3-4 minutes or 1 g in 100-250 cc D5W or NS as an infusion over 30 minutes
--Children < 12 years: 14 mg/kg/d slow IV push over 3-4 minutes (not to exceed 1 g/day)
Nebulization (for adults only)
--1 g in 1:1 dilution with sterile water or NS over 15-20 minutes

Duration of treatment
--Begin treatment with Ca-DTPA, then change to Zn-DTPA for maintenance, as indicated
--Duration of therapy depends on total body burden and response to treatment

Mechanism of action
--Chelation